弁財天

ゴフマン「専門家を信じるのではなく、自分自身で考えて判断せよ」

おい、藤井信孝と山本直樹。2003年のSARSの時の抗コロナウィルス薬はどうなったんだ? update7

【ACE I/I遺伝子型はアジア人に多い】アンジオテンシン酵素の違いを人種ターゲットのバイオテロ兵器に応用…

【ミドリ十字2020】コロナウィルスの特許情報から犯人が山口県出身の藤井信孝・京都大学薬学研究科名誉教授と山本直樹・元国立感染症研究所(NIID)エイズ研究センター長だと割れてしまうの怪…

新型コロナワクチンの年内供給目指す 米ファイザーと独社 2020年04月10日08時48分
 【ニューヨーク時事】米製薬大手ファイザーは9日、独バイオ医薬品企業ビオンテックと取り組んでいる新型コロナウイルスのワクチン開発について、順調に進めば年末までに数百万回分のワクチンを供給できる可能性があるとの見方を示した。早ければ今月末に臨床試験(治験)を始める。

Canine combination vaccines
Abstract: This invention relates to vaccines and methods for protecting dogs against disease caused by Bordetella bronchiseptica. This invention also relates to combination vaccines and methods for protecting dogs against disease or disorder caused by canine pathogens, for example, infectious tracheobronchitis caused by Bordetella bronchiseptica, canine distemper caused by canine distemper (CD) virus, infectious canine hepatitis (ICH) caused by canine adenovirus type 1 (CAV-1), respiratory disease caused by canine adenovirus type 2 (CAV-2), canine parainfluenza caused by canine parainfluenza (CPI) virus, enteritis caused by canine coronavirus (CCV) and canine parvovirus (CPV), and leptospirosis caused by Leptospira Bratislava, Leptospira canicola, Leptospira grippotyphosa, Leptospira icterohaemorrhagiae or Leptospira pomona. The vaccines of the present invention include a Bordetella bronchiseptica p68 antigen.
Type: Grant
Filed: November 20, 2007
Date of Patent: June 15, 2010
Assignee: Pfizer Inc.
Inventor: Paul J. Dominowski, Joseph C. Frantz, Richard L. Krebs, Shelly L. Shields, Robert Greg Sorensen

Recombinant feline coronavirus S proteins
Publication number: 20040063093
Abstract: The present invention relates to polypeptides and proteins useful in the diagnosis and prevention of disease caused by feline infectious peritonitis virus (FIPV) and feline enteric coronavirus (FECV).
Type: Application
Filed: August 22, 2003
Publication date: April 1, 2004
Applicant: Pfizer, Inc.
Inventor: Timothy J. Miller, Albert Paul Reed, Sharon R. Klepfer, Nancy E. Pfeiffer, Brian T. Suiter, Elaine V. Jones

Recombinant feline coronavirus S proteins
Abstract: The present invention relates to polypeptides and proteins useful in the diagnosis and prevention of disease caused by feline infectious peritonitis virus (FIPV) and feline enteric coronavirus (FECV).
Type: Grant
Filed: May 14, 2001
Date of Patent: November 4, 2003
Assignee: Pfizer Inc.
Inventor: Timothy J. Miller, Albert Paul Reed, Sharon R. Klepfer, Nancy E. Pfeiffer, Brian T. Suiter, Elaine V. Jones

Canine coronavirus S gene and uses therefor
Abstract: The present invention provides the amino acid and nucleotide sequences of a CCV spike gene, and compositions containing one or more fragments of the spike gene and encoded polypeptide for prophylaxis, diagnostic purposes and treatment of CCV infections.
Type: Grant
Filed: October 5, 2001
Date of Patent: August 5, 2003
Assignee: Pfizer Inc.
Inventor: Timothy J. Miller, Sharon Klepfer, Albert Paul Reed, Elaine V. Jones

Canine coronavirus S gene and uses therefor
Abstract: The present invention provides the amino acid and nucleotide sequences of a CCV spike gene, and compositions containing one or more fragments of the spike gene and encoded polypeptide for prophylaxis, diagnostic purposes and treatment of CCV infections.
Type: Grant
Filed: January 28, 2000
Date of Patent: April 16, 2002
Assignee: Pfizer Inc.
Inventor: Timothy J. Miller, Sharon Klepfer, Albert Paul Reed, Elaine V. Jones

Vaccine based on TGEV for protection of canines against canine coronavirus
Abstract: A method for preventing canine coronavirus in dogs is disclosed which comprises administering to a dog a live or inactivated vaccine prepared from transmissible gastroenteritis virus of swine (a TGEV vaccine). An inactivated vaccine composition for use in such a method and a process for the manufacture of the inactivated vaccine composition are described.
Type: Grant
Filed: March 30, 1999
Date of Patent: June 13, 2000
Assignee: Pfizer, Inc.
Inventor: Dale Bordt, Hans Draayer

Canine coronavirus S gene and uses therefor
Abstract: The present invention provides the amino acid and nucleotide sequences of a CCV spike gene, and compositions containing one or more fragments of the spike gene for prophylaxis, diagnostic, and treatment of CCV infections.
Type: Grant
Filed: November 23, 1994
Date of Patent: May 2, 2000
Assignee: Pfizer Inc.
Inventor: Timothy J. Miller, Sharon Klepfer, Albert Paul Reed

Vaccine based on TGEV for protection of dogs against canine coronavirus
Abstract: A method for preventing canine coronavirus in dogs is disclosed which comprises administering to a dog a live or inactivated vaccine prepared from transmissible gastroenteritis virus of swine (a TGEV vaccine). An inactivated vaccine composition for use in such a method and a process for the manufacture of the inactivated vaccine composition are described.
Type: Grant
Filed: March 27, 1991
Date of Patent: June 15, 1999
Assignee: Pfizer, Inc.
Inventor: Dale Bordt, Hans Draayer

Recombinant feline coronavirus S proteins
Abstract: The present invention provides polynucleotide molecules encoding portions of the S protein from feline infectious peritonitis virus (FIPV). The present invention further provides polynucleotide molecules encoding the entire S protein or portions thereof from feline enteric coronavirus (FECV). The polynucleotide molecules of the present invention are useful as diagnostic reagents.
Type: Grant
Filed: February 22, 1995
Date of Patent: August 28, 2001
Assignee: Pfizer Inc
Inventor: Timothy J. Miller, Albert Paul Reed, Sharon R. Klepfer, Nancy E. Pfeiffer, Brian T. Suiter, Elaine V. Jones

1991年からのコロナウィルスの老舗が自社に特許があることに気付くw

patents.justia.com→US Patent for Anti-coronavirus drug Patent (Patent # 7,495,011 issued February 24, 2009) - Justia Patents Search(2004年7月14日)

2003年のSARSのとき、抗コロナウィルス薬の特許を藤井信孝・京都大学薬学研究科名誉教授と山本直樹・元国立感染症研究所(NIID)エイズ研究センター長が連名で発表してる。

この抗コロナウィルス薬についての報道がないw、タブーなのか?w

この特許の中でSARSに対して抗HIV薬であるT20 (Fuseon)が効果的だとロックフェラー大学のデビッドホー(David D. Ho)教授他が報告してる。

「しかしながらT20のような種々な抗HIV薬はSARSウイルスに対してほとんど有効性を示さなかった」w

aRigen Pharmaceuticals, Inc.

patents.justia.com→「coronavirus」の検索結果…

#!/bin/sh

# https://patents.justia.com/search?q=coronavirus&page=7

URL="https://patents.justia.com/search?q=coronavirus&page="

seq 1 19|while read PAGE
do
    echo "page $PAGE ..."
    echo wget ${URL}${PAGE}
    wget ${URL}${PAGE}
done

なんてベタなスクリプトなんだぁw

#!/usr/bin/perl

print "<html><head><meta http-equiv=\"content-type\" content=\"text/html; charset=utf-8\"/></head><body>\n";

while (<>) {
	chomp;
	if (/\/patent\//) {
		my $line = $_;
		$line =~ tr/ / /s;
		$line =~ s/\/patent\//https:\/\/patents.justia.com\/patent\//;
		print "</p><p>".$line."<br />\n";	
	}
	if (/Publication number:/) {
		my $line = $_;
		$line =~ tr/ / /s;
		$line =~ s/<strong>//g;
		$line =~ s/<\/strong>//g;
		print $line."<br />\n";	
	}
	if (/Abstract:/) {
		my $line = $_;
		$line =~ tr/ / /s;
		$line =~ s/<strong>//g;
		$line =~ s/<\/strong>//g;
		print $line."<br />\n";	
	}
	if (/Type:/) {
		my $next_line = scalar(<>);
		$next_line =~ tr/ / /s;
		print "Type:".$next_line."<br />\n";	
	}
	if (/Filed:/) {
		my $next_line = scalar(<>);
		$next_line =~ tr/ / /s;
		print "Filed:".$next_line."<br />\n";	
	}
	if (/Date of Patent:/) {
		my $next_line = scalar(<>);
		$next_line =~ tr/ / /s;
		$next_line =~ s/<strong>//g;
		$next_line =~ s/<\/strong>//g;
		print "Date of Patent:".$next_line."<br />\n";	
	}
	if (/Publication date:/) {
		my $next_line = scalar(<>);
		$next_line =~ tr/ / /s;
		print "Publication date:".$next_line."<br />\n";	
	}
	if (/Applicant:/) {
		my $next_line = scalar(<>);
		$next_line =~ tr/ / /s;
		print "Applicant:".$next_line."<br />\n";	
	}
	if (/Assignee:/) {
		my $next_line = scalar(<>);
		$next_line =~ tr/ / /s;
		print "Assignee:".$next_line."<br />\n";	
	}
	if (/Inventor/) {
		my $next_line = scalar(<>);
		$next_line = scalar(<>);
		$next_line =~ tr/ / /s;
		print "Inventor:".$next_line."<br />\n";	
	}
}

print "</body></html>\n";

# End of FILE.

パテント情報から真犯人がわかってしまうのでは?w )CIA

patents.justia.comの「coronavirus」検索結果をテキスト・マイニングw

Inactivated canine coronavirus vaccine
Abstract: An efficacious parenterally administered inactivated canine coronavirus vaccine which provides systemic, humoral protection and also protection of the intestinal tract in dogs from infection by virulent canine coronavirus is produced. A method for propagation of the canine coronavirus and its attenuation and a method of evaluating the effectiveness of a canine coronavirus vaccine in canines is also disclosed.
Type: Grant
Filed: June 7, 1984
Date of Patent: January 28, 1986
Assignee: American Home Products Corporation
Inventor: William M. Acree, Bobby Edwards, John W. Black

コロナウィルスでいちばん古い特許は1986年1月28日の「犬コロナウィルス(canine coronavirus)のワクチン」w
やっぱ武漢→テグ(大邱)の感染ルートって食犬だろw

武漢に神殿を建てていた大邱(テグ)の「新天地」から新型コロナウィルスが拡散してルートが表面化するw

自家製の外用殺菌剤(topical antiseptic)w
いまさらながら2012年のジョン・マカフィのベリーズを復習w

日産のキャッシュ枯渇と支払い遅延とレイオフ…

中南中かぁ…

【実家近くでEM菌だんごという汚物を川に投げ込んでいたご婦人がおられるのですが、家柄として誰一人としてワクチンを受けさせていないという「反ワクチン一家」であると自認しておられます。】w

これに似た話で知り合いのお父様が外務省の医師で官僚で、その娘が反ワクチン派だったのを聞いて目が点になった記憶がある…

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